The 2020 United States Senate election in Wyoming was held on November 3, 2020, to elect a member of the United States Senate to represent the State of Wyoming, concurrently with the 2020 U.S. presidential election, as well as other elections to the United States Senate in other states and elections to the United States House of Representatives and various state and local elections. Republican Cynthia Lummis defeated Democrat Merav Ben-David by more than 46 percentage points, becoming the first female U.S. Senator from Wyoming and succeeding incumbent Republican Mike Enzi, who did not run for reelection. This was the first open Senate seat since 1996 where Enzi was first elected. The Democratic and Republican party primary elections were held on August 18, 2020.