The 2021–22 Bulgarian Cup was the 40th official edition of the Bulgarian annual football knockout tournament. It was sponsored by Sesame and known as the Sesame Kupa na Bulgaria for sponsorship purposes. The competition began on 4 September 2021 with the preliminary round and finished with the final on 15 May 2022. CSKA Sofia were the defending cup winners. They reached the final for 3rd consecutive time, but lost to Levski Sofia, who won the cup for a record 26th time and also qualified for the second qualifying round of the 2022–23 UEFA Europa Conference League.