The 2021–22 Norfolk State Spartans men's basketball team represented Norfolk State University in the 2021–22 NCAA Division I men's basketball season. The Spartans, led by ninth-year head coach Robert Jones, played their home games at the Joseph G. Echols Memorial Hall in Norfolk, Virginia as members of the Mid-Eastern Athletic Conference. They finished the season 24–7, 12–2 in MEAC Play to finish as regular season champions. They defeated Delaware State, Morgan State, and Coppin State to win the MEAC tournament championship. As a result, they received the conference’s automatic bid to the NCAA tournament as the No. 16 seed in the East Region where they lost in the first round to Baylor.