The 2021 Oklahoma State Cowboys baseball team will represent Oklahoma State University during the 2021 NCAA Division I baseball season. The Cowboys play their home games at O'Brate Stadium as a member of the Big 12 Conference. They are led by head coach Josh Holliday, in his 9th season at Oklahoma State. This will be the program's first season at O'Brate Stadium, after the 2020 season was canceled prior to the opening game at the ballpark due to the COVID-19 pandemic.