The 2022 General Tire 125 was the third stock car race of the 2022 ARCA Menards Series East season, and the 22nd iteration of the event. The race was held on Friday, April 29, 2022, in Dover, Delaware at Dover Motor Speedway, a 1 mile (1.6 km) permanent oval-shaped racetrack. The race was contested over 125 laps. At race's end, Taylor Gray of David Gilliland Racing would win, after starting from the pole and leading the most laps. This was Gray's first career east series win, and his first of the season. To fill out the podium, Jesse Love and Conner Jones of Venturini Motorsports would finish 2nd and 3rd, respectively.