A COVID-19 outbreak in the city of Shanghai, China began on February 28, 2022, and ended on August 7, 2022. The outbreak was caused by the Omicron variant and became the most widespread in Shanghai since the pandemic began two years prior. Authorities responded with mass COVID-19 testing and a strict lockdown of the city in an effort to uphold China's zero-COVID policy; the latter marked the largest one in the country since the lockdown of Hubei in early 2020. The outbreak caused substantial economic and social disruption across Shanghai with consequences felt elsewhere, and led to the spread of COVID-19 to other parts of China, including Beijing, Guangdong, and Hunan.