The 4th Annual Indie Soap Awards (ISA4) took place on February 19, 2013, once again at New World Stages in New York. The nonprofit Indie Series Network served as the charity sponsor. Colleen Zenk and Kevin Spirtas, who both landed on web series after attending ISA3, opened the show. Two former ISA winners, Martha Byrne and Hillary B. Smith, closed the show as the theater once again was filled with bubbles. The ceremony was live-streamed for the first time ever.