"6th Avenue Heartache" is a song by the American rock band The Wallflowers. It was released in April 1996 as the lead single from their second album Bringing Down the Horse. The song became their first hit, peaking at No. 8 on the US Modern Rock Tracks chart, No. 10 on the US Mainstream Rock Tracks chart, and No. 33 on the US Hot 100 Airplay chart. The background vocals in this song are by Adam Duritz from Counting Crows. Though the song was a hit on rock radio, it was overshadowed by its follow-up single, "One Headlight".