The 721st Tactical Fighter Squadron is an inactive United States Air Force unit. It was last assigned to the 450th Tactical Fighter Wing at Foster Air Force Base, Texas, where it was inactivated on 18 December 1958. The squadron was reactivated in 1954 as the 721st Fighter-Bomber Squadron at Foster, where it was initially equipped with North American F-86 Sabres. The following year, it became one of the first units to equip with the North American F-100 Super Sabre. It continued to fly the "Hun" until it was inactivated when Foster closed.