Adrián de Moxica (also written as de Múgica) (1453 – c. 1499) was a Spanish nobleman and explorer. Moxica was born to a Spanish noble family of Basque descent. In 1498 he accompanied Christopher Columbus on his third journey to the Americas, where he participated in the rebellion against Columbus in 1499 led by Francisco Roldán. Moxica was a noted participant in the rebellion, although the extent of his involvement and his role in the initiation of atrocities against the natives is uncertain. Although the rebellion was successful, de Moxica was arrested by Columbus' troops and hanged.