Alfonso of León, Lord of Molina (1202 – 6 January 1272) was an infante (prince) of León and Castile, the son of King Alfonso IX of León and his second wife Queen Berengaria of Castile. He was the brother of King Ferdinand III of Castile and León, and father of Queen Maria of Molina, wife of King Sancho IV. He became Lord of Molina and Mesa after his first marriage to Mafalda González de Lara, the heiress of those lands.