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Amissville ( /ˈeɪmɪsvɪl/ AY-mis-vil) is an unincorporated community in Rappahannock County in the U.S. commonwealth of Virginia. It is located on U.S. Route 211 about halfway between Warrenton and the small town of Washington, Virginia. The Locust Grove/R.E. Luttrell Farmstead and Meadow Grove Farm are listed on the National Register of Historic Places.