Andrzej Sapieha (1539 – October 11, 1621) was a Polish–Lithuanian nobleman (szlachcic) of the Sapieha family, who served as the Great Royal Deputy Cup-bearer of Lithuania (Podczaszy wielki litewski), castellan of Minsk, and Voivode of Polotsk and Smolensk. He was the son of , and brother of and Bohdan. After Zygmunt III Vasa came to the Polish throne in 1587, thanks to the support of the chancellor and kin Lew Sapieha, Andrzej was made the Great Royal Deputy Cup-bearer of Lithuania. On May 29, 1592 he was named castellan of Minsk.