The Archaeological Museum of Thessaloniki (Greek: Αρχαιολογικό Μουσείο Θεσσαλονίκης Arkheoloyikó Mousío Thessaloníkis) is a museum in Thessaloniki, Central Macedonia, Greece. It holds and interprets artifacts from the Prehistoric, Archaic, Classical, Hellenistic and Roman periods, mostly from the city of Thessaloniki but also from the region of Macedonia in general.