Highway 53 (AR 53, Ark. 53, and Hwy. 53) is a designation for two north–south state highways in Southwest Arkansas, United States. One route of 53.31 miles (85.79 km) begins at the Louisiana state line and runs north to US Highway 371 (US 371) south of Prescott. A second route of 32.55 miles (52.38 km) begins at Highway 24 and runs north through Gurdon to Highway 8. Both routes are maintained by the Arkansas State Highway and Transportation Department (AHTD).