August Wilhelm Hupel (25 February [O.S. 14 February] 1737 in Buttelstedt near Weimar – 7 February [O.S. 26 January] 1819 in Paide) was a Baltic German publicist, estophile and linguist. In 1766–1767, he translated for Lühhike öppetus, the first Estonian language periodical publication, edited by Peter Ernst Wilde. In 1771, he published a medical textbook, Arsti ramat nende juhhatamisseks kes tahtvad többed ärra-arvada ning parrandada (Estonian for Manual of medical diagnostics and healthcare, literally Doctor's book to instruct those who want to guess and repair ailments).