B'nai Reuben Anshe Sfard (בית הכנסת הגדול דחברה בני ראובן אנשי ספרד) was a synagogue located in the Queen Village neighborhood of Center City Philadelphia. The congregation was founded in 1883. In 1904, the congregation constructed a synagogue at 615 S 6th Street near South Street in the city's Jewish quarter. The congregation vacated the synagogue building in 1956. The synagogue building was home to the Antiquarian's Delight antique market from 1985 to 2013. The building was renovated and converted to condominiums in 2015.