Bitter Creek is an 80-mile-long stream in the U.S. state of Wyoming. It passes through several Wyoming counties including Sweetwater and Carbon. The creek rises near the Delaney Rim on the western side of Wyoming's Red Desert in Carbon County. For most of its course, Bitter Creek parallels the path of the transcontinental railroad, and the modern route of Interstate 80. It flows through the cities of Rock Springs and Green River before emptying into the Green River. It was referred to in the TV show M*A*S*H (Season 5 Episode 20) as the hometown for Cpl. Mulligan.