Blood Tie is a 1977 novel by American novelist Mary Lee Settle, published by Houghton Mifflin. The novel, her eighth, won the 1978 National Book Award for Fiction. With the award, Settle became the fourth woman to win the NBA in fiction out of 32 winners. The novel explores the going-ons of expatriates in a hotel in Ceramos on the Turkish coast. The characters in the novel are generally unlikable, and their foibles become the central focus of the novel's plot. Settle wrote the novel after returning to West Virginia, from time abroad, first in England then Italy.