Derek Cameron Wake (born January 30, 1982) is a former American football defensive end and outside linebacker. He played college football for Penn State University, and was signed by the New York Giants as an undrafted free agent in 2005. Wake has also played for the BC Lions of the Canadian Football League (CFL), earning the league's Most Outstanding Rookie Award in 2007. He recorded 39 sacks over his first two seasons in the CFL, earning Western Division All-Star honors as well as the Most Outstanding Defensive Player Award both years.