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Castelsarrasin (French pronunciation: [kastɛlsaʁazɛ̃]; Occitan: Los Sarrasins) is a commune in the Tarn-et-Garonne department in Occitanie region of France. The inhabitants are called Castelsarrasinois. It is the second most populous commune in Tarn-et-Garonne after Montauban. It is served by Castelsarrasin station on the Bordeaux-Toulouse line.