Clarksville is a hamlet in the town of New Scotland, Albany County, New York, United States. It is situated along Delaware Turnpike (New York State Route 443) in the southern part of the town at the foot of the Helderberg Escarpment. It is the site of the Clarksville Cave and has an annual Clarksville Heritage Day and Car Show. It is in the Onesquethaw Volunteer Fire Company fire protection district.