Columbine is census-designated place (CDP) in and governed by Jefferson and Arapahoe counties in Colorado, United States. The CDP is a part of the Denver–Aurora–Lakewood, CO Metropolitan Statistical Area. Located primarily in Jefferson County, Columbine lies immediately south of Denver. The population of the Columbine CDP was 24,280 at the United States Census 2010. The community lies in ZIP code 80123.