The Cotton Belt Freight Depot is a former freight depot of the St. Louis Southwestern Railway in the Near North Riverfront neighborhood of St. Louis, Missouri. It was listed on the U.S. National Register of Historic Places in 2004 and named "Best Old Building" by the Riverfront Times, a weekly newspaper in St. Louis. Since 2002, the Cotton Belt Freight Depot has been the usual location of Artica, an annual grassroots outdoor and multidisciplinary arts festival. In 2014, artists completed a large mural on the building's eastern side, visible from the nearby bride over the Mississippi River.