Cristóbal de Villalón (c. 1500 – c. 1558) was a Spanish professor and humanist. He was probably a native of Villalón de Campos. He obtained a bachelor of arts degree from the University of Alcalá in 1525 and a licentiate in logic from the University of Salamanca in 1529 or 1530. From 1530 to 1545, he was a professor of logic at the University of Valladolid. In 1532–1534, he was a private tutor in Latin and rhetoric to the family of the Counts of Lemos. He won a lawsuit against the countess for back wages. In 1545, he obtained a degree in theology from Valladolid. He may have become a priest around this time. He retired to , where he died.