De Miseria Condicionis Humane (On the wretchedness of the human condition), also known as Liber de contemptu mundi, sive De miseria humanae conditionis, is a twelfth-century religious text written in Latin by Cardinal Lotario dei Segni, later Pope Innocent III. Dei Segni, still a cardinal, began writing De Miseria Condicionis Humane sometime between late December 1194 and early April 1195. According to Robert E. Lewis, the editor of the most recent translation in English, approximately 672 manuscripts of the text are extant.