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Don Diego de Alvarado Huanitzin (or Panitzin) was a 16th-century Nahua noble. A grandson of Axayacatl, Nephew of tlatoani Moctezuma II. He was initially the tlatoani (ruler) of Ecatepec before becoming tlatoani of Tenochtitlan, as well as its first governor under the colonial Spanish system of government.