Durham is a census-designated place (CDP) comprising the primary village and surrounding development in the town of Durham, Middlesex County, Connecticut, United States. It is in the central and northeastern portions of the town, bordered to the north by the town of Middlefield and the city of Middletown. As of the 2010 census, the CDP had a population of 2,933, out of 7,388 in the entire town of Durham. The Main Street Historic District occupies 160 acres (0.65 km2) at the center of the community.