Edmund Sheffield, 1st Baron Sheffield, of Butterwick (22 November 1521 – 19 July 1549) was an English nobleman, the son of Sir Robert Sheffield (died 15 November 1531, son of Robert Sheffield and Helen Delves) and his second wife Jane Stanley, daughter of George Stanley, 9th Baron Strange and Joan le Strange, 9th Baroness Strange. Through his mother, he was a second cousin once removed of the reigning English monarch, King Henry VIII.