A destructive outbreak of nine tornadoes struck the Mississippi Valley and the Midwest during the overnight hours of November 5–6, 2005. The worst event was an F3 tornado that formed early in the morning of November 6, 2005, outside of Evansville, Indiana, United States. It was the first of several tornado events that November. The tornado resulted in 24 confirmed fatalities across the region, making it the deadliest and most destructive November tornado in Indiana's history.