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Florence is a city in, and the county seat of, Lauderdale County, Alabama, United States, in the state's northwestern corner. It is situated along the Tennessee River and is home to the University of North Alabama, the oldest college in the state. Florence is the largest and principal city of the Florence-Muscle Shoals Metropolitan Statistical Area commonly known as "The Shoals" (which also includes the cities of Muscle Shoals, Sheffield, and Tuscumbia in Colbert County). Florence is considered northwestern Alabama's primary economic hub.