Fort Niobrara National Wildlife Refuge is located in the U.S. state of Nebraska and includes 19,131 acres (77.42 km2). The refuge borders the Niobrara National Scenic River on the west and is managed by the U.S. Fish and Wildlife Service. From 1879 to 1906, the Fort Niobrara Military Reservation was located on what later became refuge lands to house a garrison of the U.S. Cavalry. After the fort was closed, the effort to preserve the region as a wildlife refuge culminated in the creation of the refuge on January 11, 1912. The refuge also manages Valentine and John and Louise Seier National Wildlife Refuges as parts of the Fort Niobrara National Wildlife Refuge Complex.