George Rex Graham (January 18, 1813 – July 13, 1894) was an American magazine editor and publisher from Philadelphia, Pennsylvania. He founded the journal Graham's Magazine at the age of 27 after buying Burton's Gentleman's Magazine and Atkinson's Casket. His journal became very popular and it was known for its generous payment to contributors. Graham worked with many notable literary figures including Edgar Allan Poe and Rufus Wilmot Griswold, and possibly sparked the enmity between the two. After Poe's death, Graham defended him from Griswold's accusations and character assassination.