German submarine U-181 was a Type IXD2 U-boat of Germany's Kriegsmarine during World War II. The submarine was laid down on 15 March 1941 at the DeSchiMAG AG Weser yard at Bremen as yard number 1021. She was launched on 30 December 1941 and commissioned on 9 May 1942 under the command of Kapitänleutnant Wolfgang Lüth. After training with the 4th U-boat Flotilla at Stettin, U-181 was attached to the 10th flotilla for front-line service on 1 October 1942, then transferred to the 12th flotilla on 1 November.