German submarine U-381 was a Type VIIC U-boat built for Nazi Germany's Kriegsmarine for service during World War II. She failed to return in May 1943 and was declared missing in unknown circumstances. The boat was laid down on 26 April 1941 at the Howaldtswerke in Kiel as yard number 12, launched on 14 January 1942 and commissioned on 25 February; Kapitänleutnant Wilhelm-Heinrich Graf von Pückler und Limpurg was her CO throughout her career. She did not sink any ships.