Giovanni Andrea II Angelo Flavio Comneno (Latin: Joannes Andreas Angelus Flavius Comnenus; 1634 – 8 April 1703) was the Grand Master of the Constantinian Order of Saint George from 1687 to 1698. Giovanni Andrea's family, the Angelo Flavio Comneno, claimed descent from the Angelos dynasty of Byzantine emperors, and Giovanni Andrea also claimed the titles "Prince of Macedonia" and "Duke and Count of Drivasto and Durazzo". The last male member of his family, Giovanni Andrea was the last grand master descended from the order's founder, Andrea Angeli. In 1687, Giovanni Andrea sold the position of grand master to Francesco Farnese, the Duke of Parma, and thereafter lived as a castellan in Piacenza.