Giovanni Francesco (Giovanfrancesco) Lottini (1512 – August 1572 ) was an Italian politician and writer. Lottini was born in Volterra in 1512. In 1530 he was accused of having seriously injured a fellow resident of Volterra and put on trial. He was secretary of Cosimo I, but in 1542 officially was removed by the same Cosimo I for acts of sodomy, but remained in his service for shady dealings. In February 1548 Cosimo I sent him to Venice, but it was he who prepared the plot against Lorenzino de' Medici, who oddly enough, the very same month, was hit by two killers from Volterra.