Gladstone is a city in Delta County in the Upper Peninsula of the U.S. state of Michigan. First settled in 1877, Gladstone's original name was Minnewasca. The population was 4,973 at the 2010 census. U.S. Highways 2 and 41 run concurrently through the city, connecting with Escanaba, nine miles (14 km) to the south. US 41 runs north to Marquette and US 2 runs east to Manistique and St. Ignace. M-35 runs northwest 52 miles (84 km) to Gwinn and merges with US 2/US 41 south to Escanaba.