The Gladstone House is a hotel in Toronto, Ontario, Canada. It was built in 1889 and named after Gladstone Avenue, next to the hotel. The Parkdale area hotel was designed by local architect George Martell Miller in the Romanesque Revival style. The Gladstone House is one of the oldest hotel buildings still operating as a hotel in Toronto. Since renovations in the early 2000s, the hotel has become an arts hub in the West Queen West neighbourhood of Toronto. In June 1973, the City of Toronto assigned a Part IV historical designation to the property.