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About: Gonadal dysgenesis     Permalink

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Gonadal dysgenesis is classified as any congenital developmental disorder of the reproductive systemin the male or female. It is the atypical development of the gonads in an embryo,with reproductive tissue replaced with functionless, fibrous tissue, termed streak gonads.Streak gonads are a form of aplasia, resulting in hormonal failure that manifests as sexual infantism and infertility, with no initiation of puberty and secondary sex characteristics. Gonadal dysgenesis arises from the failure of signalling in this tightly regulated process during early foetal development.

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