Hettesheimer Run (also known as Hettesheimer's Run) is a tributary of Bowman Creek in Wyoming County, Pennsylvania, in the United States. It is approximately 1.6 miles (2.6 km) long and flows through Noxen Township. The watershed of the stream has an area of 1.94 square miles (5.0 km2). It is not designated as an impaired waterbody. The stream was historically used as an industrial water supply. Its watershed is designated as a High-Quality Coldwater Fishery and a Migratory Fishery and the stream is Class A Wild Trout Waters.