Hisai Domain (久居藩, Hisai-han) was a feudal domain under the Tokugawa shogunate of Edo period Japan, located in Ise Province in former Hisai town (now part of the modern-day city of Tsu, Mie Prefecture). It was centered around Hisai jin'ya. Hisai Domain was a sub-domain of Tsu Domain ruled by a cadet branch of the Tōdō clan.