Hugo Karl Anton Pernice (9 November 1829 – 31 December 1901) was a German gynecologist and obstetrician born in Halle an der Saale. He was the son of legal scholar Ludwig Wilhelm Anton Pernice (1799-1861), and the father of classical archaeologist Erich Pernice (1864-1945) and Agnes Ballowitz, nee Pernice, wife of . He was an instructor and medical practitioner at Greifswald for over 40 years, retiring in 1899. In 1863 he became the first chairman of the Medizinischen Vereins Greifswald (Medical Association of Greifswald).