María Josefa Carmela of Spain (6 July 1744 – 8 December 1801) was a Princess of Naples and Sicily by birth. At the accession of her father to the Spanish throne as Charles III, she became an Infanta of Spain. Born and raised in Naples, she arrived in Spain with her family in October 1759, at age fifteen. She lived at the court of her father and later with her brother Charles IV of Spain. She remained unmarried.