Isabella Gonzaga (Italian: Isabella Gonzaga di Novellara; 1576 – 1630), was an Italian aristocrat. She was Lady Consort of San Martino dall'Argine by marriage to Ferrante Gonzaga, Lord of San Martino dall'Argine, and Duchess consort of Mantua and Montferrat by marriage to Vincenzo II Gonzaga, Duke of Mantua. She served as regent of San Martino dall'Argine during the minority of her son Scipione between 1605 and 1613.