Isatou Njie-Saidy (also spelt Aisatu N'Jie-Saidy) (born 5 March 1952) is a Gambian politician. She was Vice President of the Gambia, as well as Secretary of State for Women's Affairs, from 20 March 1997 to 18 January 2017. She is the first Gambian woman to have held the position of Vice President and one of the first women in West African politics to reach this senior position.