The Isshi incident (乙巳の変, Isshi no Hen) takes its name from the zodiological name of the year 645 during which the Taika Reform, a transformative event in Japanese Imperial history, occurred. The incident was a successful plot by Nakatomi no Kamatari, Prince Naka no Ōe and others who conspired to eliminate the main branch of the Soga clan, beginning with the assassination of Soga no Iruka.