The Italian Wars, also known as the Habsburg–Valois Wars, were a series of conflicts covering the period 1494 to 1559, fought mostly in the Italian peninsula, but later expanding into Flanders, the Rhineland and the Mediterranean Sea. The primary belligerents were the Valois kings of France, and their Habsburg opponents in the Holy Roman Empire and Spain. They were supported by various Italian states at different stages of the war, with limited involvement from England and the Ottoman Empire.