Jackson, MS Metropolitan Statistical Area is a metropolitan statistical area (MSA) in the central region of the U.S. state of Mississippi that covers seven counties: Copiah, Hinds, Holmes, Madison, Rankin, Simpson, and Yazoo. As of the 2010 census, the Jackson MSA had a population of 586,320. According to 2019 estimates, the population has slightly increased to 594,806. Jackson is the principal city of the MSA.