Joseph B. Littlejohn House is a historic home located at Oxford, Granville County, North Carolina built between about 1820 and 1832. Originally the residence of Anna Maria and Joseph Blount Littlejohn, it is a two-story, five bay, transitional Federal / Georgian style heavy timber frame dwelling. William A. Devin (1871–1959) lived in the house as a child, and Frank William Bullock Jr. owned it during the 1970s and early 1980s. It was listed on the National Register of Historic Places in 1988.